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Product Overview | |
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Description | Employing live cells as therapeutics is a direction of future drug discovery. An easy and robust method to modify the surfaces of cells directly to incorporate novel functionalities is highly desirable. However, genetic methods for cell-surface engineering are laborious and limited by low efficiency for primary cell modification. Creative Biolabs has developed a single-step chemoenzymatic CellFace™ technology platform to transfer bio-macromolecules, such as an IgG antibody (MW∼ 150 KD), to the glycocalyx on the surfaces of live cells. Requiring no genetic modification, our CellFace™ allows for any antibody to be conjugated to the stimulatory surface receptors of immune cells to yield the additive effect of superior tumor targeting to its already potent and off-the-shelf biologic drug payloads. We applied CellFace™ to construct the CellFace™ cell-antibody conjugation (CAC). CellFace™ CAC can be prepared from multiple immune cells and stem cells, such as T cells, NK cells, macrophages, and mesenchymal stem cells. The modified CAC is expected to overcome the challenges that have prevented cell therapies from effectively targeting solid tumors. |
Available Formats | CellFace™ T Cell-Antibody (Anti-GRP94) Conjugation CellFace™ NK Cell-Antibody (Anti-GRP94) Conjugation CellFace™ MA Cell-Antibody (Anti-GRP94) Conjugation CellFace™ MSC Cell-Antibody (Anti-GRP94) Conjugation CellFace™ HSC Cell-Antibody (Anti-GRP94) Conjugation |
Engineered Molecules | Antibody |
Cell Type | T Cell; NK Cell; Macrophage; HSC; MSC; TIL; CIK; γδ T Cell; Treg; Dendritic Cell; Fibroblast; Chondrocyte; iPSC; B Cell |
Application Notes | The CAC can be customized with both cell lines and primary cells according to customer needs. Please contact us for specific cells you needs. |
Target | |
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Target | GRP94 |
Official Name | HSP90B1 |
Full Name | heat shock protein 90kDa beta (Grp94), member 1 |
Synonyms | HSP90B1; heat shock protein 90kDa beta (Grp94); member 1; ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m; endoplasmin; tumor rejection antigen 1; epididymis luminal protein 35; 94 kDa glucose-regulated protein; tumor rejection antigen (gp96) 1; endothelial cell (HBMEC) glycoprotein; heat shock protein 90 kDa beta member 1; stress-inducible tumor rejection antigen gp96; epididymis secretory sperm binding protein Li 125m |
Quality Control | |
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Research Use Only | For research use only, not for diagnostic or therapeutic use. |
All services are only provided for research purposes and Not for clinical use.