Inquiry

CellFace™ Cell-Aptamer (Anti-HMGB1) Conjugation (CAT#: CF-1022-ZP172)

DataSheet

Product Overview
Description	Employing live cells as therapeutics is a direction of future drug discovery. An easy and robust method to modify the surfaces of cells directly to incorporate novel functionalities is highly desirable. However, genetic methods for cell-surface engineering are laborious and limited by low efficiency for primary cell modification. Creative Biolabs has developed a single-step chemoenzymatic CellFace™ technology platform to transfer bio-macromolecules, such as an IgG Aptamer (MW∼ 150 KD), to the glycocalyx on the surfaces of live cells. Requiring no genetic modification, our CellFace™ allows for any Aptamer to be conjugated to the stimulatory surface receptors of immune cells to yield the additive effect of superior tumor targeting to its already potent and off-the-shelf biologic drug payloads. We applied CellFace™ to construct the CellFace™ cell-Aptamer conjugation (CAC). CellFace™ CAC can be prepared from multiple immune cells and stem cells, such as T cells, NK cells, macrophages, and mesenchymal stem cells. The modified CAC is expected to overcome the challenges that have prevented cell therapies from effectively targeting solid tumors.
Available Formats	CellFace™ T Cell-Aptamer Conjugation CellFace™ NK Cell-Aptamer Conjugation CellFace™ MA Cell-Aptamer Conjugation CellFace™ MSC Cell-Aptamer Conjugation CellFace™ HSC Cell-Aptamer Conjugation
Engineered Molecules	Aptamer
Cell Type	T Cell; NK Cell; Macrophage; HSC; MSC; TIL; CIK; γδ T Cell; Treg; Dendritic Cell; Fibroblast; Chondrocyte; iPSC; B Cell
Application Notes	The CAC can be customized with both cell lines and primary cells according to customer needs. Please contact us for specific cells you needs.

Target
Target	HMGB1
Official Name	HMGB1
Full Name	high mobility group box 1
Synonyms	HMG1; HMG3; HMG-1; SBP-1

Quality Control
Research Use Only	For research use only, not for diagnostic or therapeutic use.

All services are only provided for research purposes and Not for clinical use.

ONLINE INQUIRY

USA

United Kingdom

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.