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CellFace™ Cell-Aptamer (Anti-TNF-R-II) Conjugation (CAT#: CF-1022-ZP255)

DataSheet

Product Overview
Description	Employing live cells as therapeutics is a direction of future drug discovery. An easy and robust method to modify the surfaces of cells directly to incorporate novel functionalities is highly desirable. However, genetic methods for cell-surface engineering are laborious and limited by low efficiency for primary cell modification. Creative Biolabs has developed a single-step chemoenzymatic CellFace™ technology platform to transfer bio-macromolecules, such as an IgG Aptamer (MW∼ 150 KD), to the glycocalyx on the surfaces of live cells. Requiring no genetic modification, our CellFace™ allows for any Aptamer to be conjugated to the stimulatory surface receptors of immune cells to yield the additive effect of superior tumor targeting to its already potent and off-the-shelf biologic drug payloads. We applied CellFace™ to construct the CellFace™ cell-Aptamer conjugation (CAC). CellFace™ CAC can be prepared from multiple immune cells and stem cells, such as T cells, NK cells, macrophages, and mesenchymal stem cells. The modified CAC is expected to overcome the challenges that have prevented cell therapies from effectively targeting solid tumors.
Available Formats	CellFace™ T Cell-Aptamer Conjugation CellFace™ NK Cell-Aptamer Conjugation CellFace™ MA Cell-Aptamer Conjugation CellFace™ MSC Cell-Aptamer Conjugation CellFace™ HSC Cell-Aptamer Conjugation
Engineered Molecules	Aptamer
Cell Type	T Cell; NK Cell; Macrophage; HSC; MSC; TIL; CIK; γδ T Cell; Treg; Dendritic Cell; Fibroblast; Chondrocyte; iPSC; B Cell
Application Notes	The CAC can be customized with both cell lines and primary cells according to customer needs. Please contact us for specific cells you needs.

Target
Target	TNF-R-II
Official Name	TNFRSF1B
Full Name	TNF receptor superfamily member 1B
Synonyms	p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

Quality Control
Research Use Only	For research use only, not for diagnostic or therapeutic use.

All services are only provided for research purposes and Not for clinical use.

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