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Applications of Cell Surface Engineering in Lymphocytes

Immuno-engineering is an emerging field of research with many opportunities to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Based on the improved understanding of the molecular and physical mechanics of lymphocyte activation, as well as the increasingly evolving technology, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer (NK) cells are in preclinical and clinical development. Lymphocyte surface engineering has been a very promising approach in developing novel lymphocyte-based therapeutics.

Introduction of Lymphocytes Surface Engineering

Originated from stem cells in the bone marrow and primarily exist in the blood and lymphoid tissues, lymphocytes include T-Cells, B-Cells and NK cells, both of which offer great promise in the fight against infections and cancers. Especially, T cells and B cells play important roles in protective activities and immune response, such as antigen detection, pathogen clearance, disease site infiltration, and abnormal cell destruction. Therefore, lymphocytes have become promising candidates for cancer immunotherapy and drug delivery.

Genetically engineering lymphocytes is a robust modification technique, but has a number of significant drawbacks, such as complicated procedures and potential toxicities. Surface engineering of lymphocytes has emerged as a powerful and compatible complement to trigger an enhanced immune reaction and improve cell-based therapeutics.

Applications of Lymphocytes Surface Engineering

Schematic of maleimide-based conjugation to cell surface thiols. Fig.1 Schematic of maleimide-based conjugation to cell surface thiols. (Stephan, 2010)

Schematic of T cell functionalization and cell-mediated delivery of SN-38 NCs into tumors. Fig.2 Schematic of T cell functionalization and cell-mediated delivery of SN-38 NCs into tumors. (Huang, 2015)

DOX-A@T cells potentiates immune response in tumor microenvironment. Fig.3 DOX-A@T cells potentiates immune response in tumor microenvironment. (Liu, 2019)

Engineering lymphocytes’ surface with natural ligands, functional biological components, or synthetic materials is a unique and powerful strategy to modulate cell function. It is also a promising strategy to enhance cell therapy via the conjugation of adjuvant drug-loaded nanoparticles to the surfaces of therapeutic lymphocytes. Based on leading-edge facilities and profound knowledge, Creative Biolabs has made many endeavors to develop lymphocyte surface engineering techniques to endow lymphocytes with new functions to enhance drug delivery efficiency and immunotherapy effects. Please contact us for more detailed information to know how we can help.

References

  1. Stephan, M. T.; et al. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nature medicine. 2010, 16(9): 1035-1041.
  2. Huang, B.; et al. Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells. Science translational medicine. 2015, 7(291): 291ra94-291ra94.
  3. Liu, L.; et al. Nano-engineered lymphocytes for alleviating suppressive tumor immune microenvironment. Applied Materials Today. 2019, 16: 273-279.

All services are only provided for research purposes and Not for clinical use.

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