Lymphocytes Surface Engineering Service

The ability to modify cells and tailor their functions according to intended therapeutic designs has been the central scientific interest in the field of cell-based therapeutics. Lymphocytes offer great promise in the fight against infections and cancers; therefore, lymphocyte surface engineering is a very promising approach in developing novel lymphocyte-based therapeutics. Building upon deeply understanding of the molecular mechanics of lymphocyte activation and regulation, Creative Biolabs has developed various cell surface engineering strategies to engineer lymphocytes (such as T-Cells, B-Cells and natural killer (NK) cells, etc.) with desired properties and functions.

Introduction of Cell Surface Engineering

As cell therapy has emerged as a prominent therapeutic strategy, cell surface engineering providing new characteristics and functions to cells has drawn continuous interest in basic research and clinical therapeutics. Cell surface engineering usually involves non-genetic engineering strategy, which has emerged as a powerful and compatible complement to enhance the function of cells or cell-based therapeutics. Amongst, covalent chemical conjugation and noncovalent physical bioconjugation have been widely developed to engineer the surface of cells. T-cells, NK cells and other lymphocytes, have been favored candidates for cell-based cancer immunotherapy. Therefore, lymphocyte surface engineering has been a fast-developing research field.

Fig.1 Modes of non-genetic cell surface engineering techniques. (Lee, 2018)

Applications of Cell Surface Engineering

Cellular surface engineering with different biomaterials conjugates contributes to the progress of biomedical applications. It provides the driving force for the development of cell-based therapy in the following areas:

• Investigation of adding new functions
• Reducing graft rejection for transplantation by masking the surface antigens
• Creation of heterogeneous cluster of cells by cell-to-cell attachment
• Enhancing immune effector functions
• Programing cell-to-cell interactions

Cases of Lymphocytes Surface Engineering

Surface engineering of biomolecules is key to deliver the desired properties for lymphocytes. This engineering may trigger an enhanced immune reaction and has been a novel alternative approach for immuno-oncology.

Table.1 Summary of various surface engineering features for lymphocytes. (Ben-Akiva, 2017)

Lymphocytes Surface Engineering Service

Focused on the controlled delivery of biomolecules to different cell types, Creative Biolabs is dedicated to offering cell surface engineering services that can be tailored to modulate cellular function and interactions. In terms of lymphocytes, we provide non-genetic cell surface engineering services to activate or deactivate T-Cells, B-Cells and NK cells. We have developed a series of engineering techniques to offer more transient and reversible modifications to lymphocytes, such as chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, etc. We can manipulate and modify lymphocytes at a non-genetic level, usually using the characteristics of lipids, proteins, and glycans present in the cell membrane. The conjugates, including proteins, surface receptors, antibodies, peptides, cytokines, genetic materials, and protective polymers, have been used to endow specific functions to lymphocytes.

Known for our deeply-rooted expertise and abundant experience in cell surface engineering, Creative Biolabs is dedicated to offering lymphocyte surface engineering services to modify lymphocytes with some therapeutic molecules, artificial receptors, and multifunctional nanomaterials, thus accelerating the development of cell-based therapeutics. If you want to get more information, please feel free to contact us.

References

1. Lee, D. Y.; et al. Cell surface engineering and application in cell delivery to heart diseases. Journal of Biological Engineering. 2018, 12(1): 1-11.
2. Ben-Akiva, E.; et al. Surface engineering for lymphocyte programming. Advanced drug delivery reviews. 2017, 114: 102-115.