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Drug Delivery

Cell membrane-coated drug delivery exploits a novel top-down approach to faithfully transferring the entire cell exterior, including both lipids and membrane-associated proteins, onto synthetic nanoparticle drugs. This new class of biomimetic nanoparticle drugs has shown significant therapeutic potentials. Committed to the application of cell surface engineering in drug delivery for years, Creative Biolabs is experienced and professional in providing high-quality cell surface conjugation services to global customers.

Introduction

How to design a drug carrier that can specifically deliver drugs to the site of disease is always the main focus of current pharmaceutical research. Thanks to recent advances in material science and nanotechnology, many nanoformulations, such as liposomes, micelles, and nanoparticles, have been developed and some of them have been used in the clinic or approaching the clinical translation. Cell membrane-coated nanoparticles have unleashed the promising potential of exploiting natural functionalities of the source cells for effective drug targeting. While this class of biomimetic nanoparticles was developed not long ago, it has already demonstrated the capability of pushing the envelope of targeted nanoparticle drug delivery.

Schematic representation of nanoparticle surface functionalization through cell membrane coating. Fig.1 Schematic representation of nanoparticle surface functionalization through cell membrane coating. (Gao, 2015)

Methods and Applications

A schematic illustration of modulating antibacterial immunity <em>via</em> bacterial membrane-coated nanoparticles. Fig.2 A schematic illustration of modulating antibacterial immunity via bacterial membrane-coated nanoparticles. (Gao and Zhang, 2015)

In addition to presenting native membrane antigens, cell membrane-coated nanoparticles can also carry and deliver foreign antigens such as bacterial toxins to the immune system as toxoid vaccines, which are inactivated forms of toxins that can be administered to mount an anti-toxin immune response.

Services at Creative Biolabs

As a professional cell surface engineering services provider, Creative Biolabs has established a comprehensive technology platform. The scope of our services covers cell-nucleic acids conjugate (e.g. DNA-protein conjugate, lipid-DNA conjugate), cell-covalent conjugation (e.g. cell surface-based chemical conjugation, cell surface-based metabolic conjugation), cell-noncovalent physical bioconjugation (e.g. cell surface-based biotinylation modification, cell surface-based electrostatic interaction modification).

With years of experience focusing on cell surface engineering, Creative Biolabs will be your best partner. If you are interested in cell our services, please feel free to contact us for more information.

Reference

  1. Gao, W.; Zhang, L. Coating nanoparticles with cell membranes for targeted drug delivery. J Drug Target. 2015, 23(7-8): 619-26.

All services are only provided for research purposes and Not for clinical use.

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