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Applications of Cell Surface Engineering in Monocytes/Macrophages

Engineering cell surfaces with natural or synthetic materials is a unique and powerful strategy to modulate cell function, including monocytes and macrophages. This sophisticated technology utilizes engineering, chemistry, and biology techniques to conjugate cell surface with natural ligands, functional biological components, or synthetic materials to provide new characteristics and functions to cells.

Importance of Cell Surface Engineering in Monocytes/Macrophages

Monocytes are an important type of white blood cells that form macrophages and dendritic cells, representing 10% of the leukocytes in humans and playing key roles in inflammation, infection, and homeostasis. Monocytes and macrophages share many common biological functions and the conversion from monocytes to macrophages is a highly dynamic process in vivo. Monocytes/macrophages have shown multifaceted advantages in drug delivery, including but not limited to:

Over the past decade, modification of monocytes/macrophages surfaces with natural or synthetic materials (cell receptors and respective ligands, downstream signaling pathways, external stimuli, and nanomaterials) has been exploited to enhance their efficiency of drug delivery and immune modulation.

Representation of the cell surface structures and the principal methodologies used for cell engineering. Fig.1 Representation of the cell surface structures and the principal methodologies used for cell engineering. (Custódio, 2016)

Applications of Cell Surface Engineering in Monocytes/Macrophages

Surface-engineering is already being applied to many biomedical areas, such as bioimaging, cell therapy, tissue engineering, cell tracking and sensing, drug delivery, and immune modulation. With the rapid development of new biological tools, many endeavors have been made to develop surface engineering techniques to endow cells with new functions. Based on leading-edge facilities and profound knowledge, Creative Biolabs is dedicated to offering high-quality monocytes/macrophages engineering services to enhance drug delivery efficiency and modulate immunity, such as the antigen-capturing ability, recognition, and presentation of macrophages.

References

  1. Custódio, C. A.; Mano, J. F. Cell surface engineering to control cellular interactions. ChemNanoMat. 2016, 2(5): 376-384.
  2. Sugimoto, S.; Iwasaki, Y. Surface modification of macrophages with nucleic acid aptamers for enhancing the immune response against tumor cells. Bioconjugate chemistry. 2018, 29(12): 4160-4167.
  3. Holden, C. A.; et al. Surface engineering of macrophages with nanoparticles to generate a cell-nanoparticle hybrid vehicle for hypoxia-targeted drug delivery. International journal of nanomedicine. 2010, 5: 25.
  4. Cao, H.; et al. Liposomes coated with isolated macrophage membrane can target lung metastasis of breast cancer. ACS nano. 2016, 10(8): 7738-7748.

All services are only provided for research purposes and Not for clinical use.

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