Cell-Drug Conjugate (CDC) Service

Cell-based therapies have revealed distinctive therapeutic potential in the field of cancer immunotherapy. Therefore, modifying cells and manipulating their functions to achieve the desired treatment has become a major interest in the field of biomedical research. Here, Creative Biolabs has developed cell surface-based cell-drug conjugates (CDC) that can bring a new generation of cancer treatment products. Unlike conventional cytotoxic drug monotherapy which is considered unsafe and ineffective, our CDC-based cell therapy is designed to specifically target and kill tumor cells while retaining healthy cells. This highly potent cell conjugate possesses limited side effects and provides more precise treatments than chemotherapeutic toxic payloads.

End-to-End CAC Service

To provide best-in-class CDC development services, Creative Biolabs brings together the most renowned cell-drug conjugate experts and long-term experience in cell modification. Don't miss the opportunity to enter the clinic by working with service provider who provides the strongest cell therapy tools on the market!

Design

Cell line preparation and drug procurement

Cell Lines

Creative Biolabs provides hundreds of quality-controlled cell lines to advance your research. Currently, we have more than 100 cell lines including cancer cell lines with different disease states, immune cell lines, stem cells from multiple sources, and control cell lines. All of these cell lines have been validated under our strict quality control testing and free from mycoplasma, and undesirable cells and foreign factors.

Available cell lines

Immune Cells	Stem Cells	Disease State Cells
T cells	Embryonic & Induced Pluripotent Stem Cells	Bone Marrow Mononuclear Cells (BMMCs)
B cells	Hematopoietic Stem Cells	Rheumatoid Arthritis and Osteoarthritis Fibroblasts
NK cells	Mesenchymal Stem Cells	Lung Bronchial Epithelial Cells Hepatocytes
Dendritic cells	Neural Stem Cells	Hepatocytes
Monocytes	Cancer Stem Cells	Breast Cancer Cells
Neutrophils	...	Hematopoietic Malignancies Cells
...		Renal Cells
		...

Drug Molecules

Creative Biolabs can help you source off-the-shelf drug products, or assist you in custom synthesis of drugs of interest. In summary, the drug payload for coupling can be obtained in three ways:

Off the shelf
Customer provided
Custom synthesis

Conjugation

Conjugate antibody to cell surface in minutes

Based on our CellFace™ conjugate technology platform, we utilize fucosyltransferases (Fuc T) to transfer drug to the surface of living cells in minutes. This one-step approach developed by scientist team is a fast, simple, and cost-effective technique for cell surface engineering. Using this method, any drug payload can be introduced to the cell surface without genetic modification of the host cells.

Analysis

Cell-drug conjugate characterization

Creative Biolabs provides a full set of cell-drug conjugate characterization services including:

CDC Characterization

Drug-to-cell ratio (DCR): HIC chromatography
Drug load distribution assessment: HIC chromatography
Site of payload conjugation: RP-HPLC
% free drug: LC-MS
% aggregation: SEC-HPLC
Payload release:LC-MS
Binding analysis: ELISA, SPR and flow cytometry
In vitro evaluation (binding, internalization, potency etc.)
In vitro oncology and toxicology evaluation
Stability: differential scanning calorimetry
Other QC analysis available upon request

ELISA

HIC chromatography

RP-HPLC

Linker-Payload Characterization

Potency
Solubility
Plasma and PH stability
Payload release kineticse
Purity, chemical stability and other analytical properties uopon request

Why choose Creative Biolabs for your CDC development?

Precision

CDCs exhibit selective cytotoxicity by precisely targeting only a small subset of cells

Integration

We provide a one stop shop to meet all your CDC development needs

Developability

Our CDCs are IP-free. You have full ownership of the products which can be translated into the clinic.