Cell-Covalent Conjugation Service

Cell surface engineering is one of the most promising solutions to improve therapeutic feasibility and effectiveness. By providing high-quality and customized services, Creative Biolabs is a reliable partner for your cell-covalent conjugation requirements.

Cell-Covalent Conjugation Service

Cell therapy has emerged as a prominent therapeutic strategy. Cell surface engineering that can provide new characteristics and functions to cells has drawn continuous interest from researchers in biomedical science. In contrast to the traditional genetic engineering of cells, Creative Biolabs has developed a non-genetic cell-surface engineering technology that allows for transient and reversible modifications to control cellular functions and improve therapeutic purposes. By implementing a state-of-the-art CellFace™ conjugate technology platform and expertise in biochemistry, we offer covalent conjugation, one of the cell-surface engineering technology for various biomaterials, including proteins, surface receptors, antibodies, peptides, lipids, and protective polymers. Based on our deep understanding of all types of covalent conjugation strategies, Creative Biolabs also offers many current methods of cell surface modification to meet our customers' specific requirements, including but not limited to:

1. Direct chemical conjugation (amine-reactive strategies and thiol-reactive strategies)
2. Indirect conjugation (enzyme-mediated strategies, metabolic-mediated strategies, and polymeric encapsulation strategies)

Fig.1 Schematic diagram of cell-covalent conjugation.¹

• Cell Surface-based Chemical Conjugation

Chemical conjugation is the most straightforward method that takes advantage of surface-exposed functional groups on the membrane proteins as grafting points. Based on our deep understanding of cell-based chemical conjugation, we offer various chemical conjugation methods to enable multiple functional groups (such as manipulate lipids, proteins, or glycans) conjugation for your specific requirement.

• Cell Surface-based Metabolic Conjugation

With our well-established cell surface engineering platform, the experienced scientists at Creative Biolabs are dedicated to offering cell surface-based conjugation using metabolic oligosaccharide engineering. Our metabolic introduction strategy can add various functional groups such as biotin, azide, and ketone groups to living cell surfaces.

• Cell Surface-based Enzymatic Conjugation

The enzymatic-mediated modifications are that reactive groups must be generated or exposed through enzymatic treatment of the originally existing cell surface molecules. This enzymatic conjugation method simplifies the process of functionalization of virtually any cell type. Currently, Creative Biolabs could offer this robust and straightforward enzymatic approach to enable engineering of the cell membrane for research or therapy under physiological reaction conditions that ensure the viability of the modified cells.

• Cell Surface-based Polymer Conjugation

Surface modification of living cells with natural or synthetic polymers is a powerful and useful biomedical science and engineering tool. Creative Biolabs provides various synthetic and natural polymers for surface modification of cells to our customers and will never leave you with an unresolved issue with our well-established platform.

Creative Biolabs has years' experience in cell surface conjugate development and offers you the best advice and support to advance your programs. If you are interested in our cell-covalent conjugation services, please feel free to contact us for more detailed information.

Reference

1. Lee, Daniel Y., et al. "Cell surface engineering and application in cell delivery to heart diseases." Journal of Biological Engineering 12 (2018): 1-11. Distributed under Open Access license CC BY 4.0, without modification.