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Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at the 13th Annual World ADC San Diego and the 13th Annual World Multispecific Summit in September, the 10th Annual Immuno-Oncology Summit in October, and the Antibody Engineering & Therapeutics (US) 2022 in December for expert consultation on your drug discovery projects. Shoot an email to arrange an in-person meeting!

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Cell Surface-based Enzymatic Conjugation Service

The understanding and manipulation of the cell surface are important topics for fundamental studies of cell behavior and translational research on novel biotechnical applications and therapeutic development. As an industry-leading cell surface engineering services provider, Creative Biolabs has accumulated rich precious experience in practice. With extensive experience and strong foundations, we are capable of providing high-quality cell surface-based enzymatic conjugation services.

Introduction of Cell Surface-based Enzymatic Conjugation

Incorporation of unnatural moieties into the cell surfaces can be achieved by incubating the cells with exogenous enzymes in proper conditions, which can catalyze the enzymatic reaction on the cell surfaces in the presence of the necessary substrates. The enzymes either can recognize the naturally existing substrate on the cell surface and transform it into an unnatural functional group or can recognize a specific sequence introduced by traditional molecular biology methods. Due to the mild reaction conditions which are generally compatible with live cells, covalent bond formation, and substrate specificity, enzyme-mediated engineering of live cell surface provides an excellent opportunity to load a cargo moiety including peptides, proteins, and nanoparticles to the cell surface.

Methods and Applications

 Cell surface modification by using exogenous enzymes. Fig.1 Cell surface modification by using exogenous enzymes. (Bi, 2018)

Services at Creative Biolabs

Focusing on cell membrane engineering research over years, Creative Biolabs is professional in this field. We have equipped our platform with advanced facilities and accumulated rich experience during the years of practice. With great foundations and excellent scientific staff, we are confident in the quality of our services.

As a global-leading CRO company, Creative Biolabs aspires to provide every customer satisfying services and we are trying our best to do so. If you are interested in cell surface-based enzymatic conjugation services or other cell membrane engineering services, please don't hesitate to contact us for more information.

Reference

  1. Bi, X.; et al. Chemical and enzymatic strategies for bacterial and mammalian cell surface engineering. Chemistry. 2018, 24(32): 8042-8050.

All services are only provided for research purposes and Not for clinical use.

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