The main limitation of cell-based therapies is the viability and function of transplanted cells. After cell transfer, therapeutic cells often rely on adjuvants, such as the simultaneous delivery of drugs. These adjuvants are designed to maximize the donor cell efficacy, phenotype and / or durability in vivo.
Here at Creative Biolabs, we developed a method via the conjugation of adjuvant–loaded nanoparticles to the surfaces of therapeutic cells to enhance cell therapy. This approach is a simple and generalizable strategy to augment cytoreagents while minimizing the systemic side effects of adjuvants.
Nucleic Acids-loaded NP
To provide best-in-class CALNP development services, Creative Biolabs brings together the most renowned cell engineering experts and long-term experience in cell surfce modification. Don't miss the opportunity to enter the clinic by working with service providers who provide the strongest cell therapy tools on the market!
Cell line and NP design
Creative Biolabs provides a variety of the industry-grade cells lines to meet your cell-related research needs. Usinf strict quality control testing, all of our cell lines are free of contaminiaton (e.g., mycoplasma), and undesired foreign factors such as fungi, viruses. In addition, our comprehensive cell portfolio is also ideal for use in clinical translation. Instrumentation platforms from cell separation, flow cytometry, to closed-system cell culture make automated processing at your fingertips. Contact us to discover how our solutions can advance your cell-related research.
Available cell lines
Disease State Cells
|T cells||Embryonic & Induced Pluripotent Stem Cells||Bone Marrow Mononuclear Cells (BMMCs)|
|B cells||Hematopoietic Stem Cells||Rheumatoid Arthritis and Osteoarthritis Fibroblasts|
|NK cells||Mesenchymal Stem Cells||Lung Bronchial Epithelial Cells Hepatocytes|
|Dendritic cells||Neural Stem Cells||Hepatocytes|
|Monocytes||Cancer Stem Cells||Breast Cancer Cells|
|Neutrophils||...||Hematopoietic Malignancies Cells|
Nanoparticles have many applications in biology and medicine and are used as biosensors, cell probes, and drug delivery vehicles. In order to achieve these specific applications of nanoparticles, it is necessary to have the ability to design the shape, size, and modify of the surface of NPs.
Creative Biolabs has extensive expertise in the design and synthesis of adjuvant-loaded NP. We provide high-quality customized NP design services and peptide synthesis services for research, diagnostic, pre-clinical and commercial applications.
|Composition||A variety of metals, oxides, semiconductors and polymer nanomaterials are avalible. We also provide assistance with existing protocols for process optimization, scale-up and cGMP-compliant manufacturing.|
|Size||We can produce a variety of particle sizes and other sizes can be customized as required. We can also produce polymers up to 1 µm in size, oxide particles and core / shell structures.|
|Surface||Our standard nanoparticles have a variety of available anionic and cationic end-capping ligands. In addition, we can manufacture nanomaterials with specific functional groups, polymers, and biomolecules.|
|Concentration||We have developed techniques for processing and stabilizing high-concentration particles. UV-visible spectroscopy and ICP mass spectrometry are used to accurately measure material concentration and extinction coefficient.|
"One-Step in Minutes"
Based on our CellFace™ conjugate technology platform, we utilize fucosyltransferases (Fuc T) to transfer NP to the surface of living cells in minutes. This one-step approach developed by scientist team is a fast, simple, and cost-effective technique for cell surface engineering. Using this method, any adjuvant-loaded NPs can be introduced to the cell surface without genetic modification of the host cells.
Cell-NP conjugates characterization
Creative Biolabs provides a full set of cell-NP conjugate characterization services including:
Targeted drug delivery
All services are only provided for research purposes and Not for clinical use.