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Cell Tracking

Cell surface engineering has been playing an important role in cell tracking by increasing the sensitivity of imaging. As a professional cell surface engineering services provider, Creative Biolabs is experienced and we have accomplished hundreds of customer-satisfied projects.

Introduction

Tracking the transport and destination of cells systemically or locally injected into a body is necessary to ascertain their homing and engraftment. As such, efforts are being made to image transplanted cells using noninvasive bioimaging approaches, including magnetic resonance imaging, positron emission tomography, optoacoustic tomography, and luminescence/fluorescence-based in vivo imaging systems. To increase imaging sensitivity, cells are labeled with a series of molecules or nanoparticles to generate positive or negative contrast in clinical images captured with the appropriate bioimaging instrument.

Methods and Applications

Schematic of trivalent 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)−gadolinium(III) complex coating a cell surface and following enhancement of the T1-weighted magnetic resonance imaging result. Fig.1 Schematic of trivalent 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)−gadolinium(III) complex coating a cell surface and following enhancement of the T1-weighted magnetic resonance imaging result. (Park, 2018)

In vivo imaging system that captures near-infrared fluorescence (NIRF) of the Cy5-modified human adipose-derived mesenchymal stem cells in the ischemic hindlimb. Fig.2 In vivo imaging system that captures near-infrared fluorescence (NIRF) of the Cy5-modified human adipose-derived mesenchymal stem cells in the ischemic hindlimb. (Park, 2018)

Services at Creative Biolabs

Focusing on surface engineering research for years, Creative Biolabs has accumulated rich experience and we have gradually developed our own technology platform. With advanced facilities and excellent scientific staff, our platform offering high-quality cell surface engineering services including but not limited to:

With professional expertise and strong foundations, Creative Biolabs is eager to bring every client top-rated customer experience. If you are interested in cell surface engineering services, please don’t hesitate to contact us for more information.

Reference

  1. Park, J.; et al. Engineering the surface of therapeutic "living" cells. Chem Rev. 2018, 118(4): 1664-1690.

All services are only provided for research purposes and Not for clinical use.

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