Cell-Peptide Conjugate (CPC) Service

Peptides, as a new material that can both display protein functions and have a high degree of modularity in molecular design, have drawn great interest in the field of biomedicine. A large number of peptide products have been successfully commercialized over the past few decades. However, their functions are greatly limited by the following reasons: (i) their target binding affinity and selectivity are lower than proteins; (ii) easily digested by proteases in the biological environment; (iii) short circulating half-life.

Creative Biolabs is proud to announce the proprietary technology of a custom conjugation service for conjugates of synthetic peptides to cells for cell screening and in vivo studies.

Your One Stop Source for Cell-Peptide Conjugates

To provide best-in-class CPC development services, Creative Biolabs brings together the most renowned cell-peptide conjugate experts and long-term experience in cell modification. Don't miss the opportunity to enter the clinic by working with service provider who provides the strongest cell therapy tools on the market!

Design

Cell line preparation and drug procurement

Cell Lines

Creative Biolabs provides hundreds of quality-controlled cell lines to advance your research. Currently, we have more than 100 cell lines including cancer cell lines with different disease states, immune cell lines, stem cells from multiple sources, and control cell lines. All of these cell lines have been validated under our strict quality control testing and free from mycoplasma, and undesirable cells and foreign factors.

Available cell lines

Immune Cells	Stem Cells	Disease State Cells
T cells	Embryonic & Induced Pluripotent Stem Cells	Bone Marrow Mononuclear Cells (BMMCs)
B cells	Hematopoietic Stem Cells	Rheumatoid Arthritis and Osteoarthritis Fibroblasts
NK cells	Mesenchymal Stem Cells	Lung Bronchial Epithelial Cells Hepatocytes
Dendritic cells	Neural Stem Cells	Hepatocytes
Monocytes	Cancer Stem Cells	Breast Cancer Cells
Neutrophils	...	Hematopoietic Malignancies Cells
...		Renal Cells
		...

Peptide design and synthesis

Creative Biolabs has extensive expertise in the synthesis of artificial peptides. We provide high-quality custom peptide design services (Antigen Profiler System) and peptide synthesis services for research, diagnostic, pre-clinical and commercial applications. The peptides produced by our state-of-art synthesis platform can be conjugated to a wide variety of molecules, not just cells.

Additional peptide modification options are available:

Phosphorylation modification
Methylation modification
Biotinylation modification
Glycosylation modification
Amidation modification
Addition of dye labels

Conjugation

"One-Step in Minutes"

Based on our CellFace™ conjugate technology platform, we utilize fucosyltransferases (Fuc T) to transfer Peptide to the surface of living cells in minutes. This one-step approach developed by scientist team is a fast, simple, and cost-effective technique for cell surface engineering. Using this method, any drug payload can be introduced to the cell surface without genetic modification of the host cells.

Analysis

Cell-peptide conjugate characterization

Creative Biolabs provides a full set of cell-Peptide conjugate characterization services including:

CPC Characterization

Peptide-to-cell ratio (DCR): HIC chromatography
Cytotoxicity study
Cell apoptosis detection
Cell-cycle analysis
Binding analysis: ELISA, SPR and flow cytometry
In vitro evaluation (binding, internalization, potency, etc.)
In vivo oncology and toxicology evaluation
Stability: differential scanning calorimetry
Other QC analysis available upon request

ELISA

HIC chromatography

RP-HPLC

Linker-Payload Characterization

Potency
Solubility
Plasma and PH stability
Payload release kineticse
Purity, chemical stability and other analytical properties uopon request

Why choose Creative Biolabs for your CDC development?

Precision

CDCs exhibit selective cytotoxicity by precisely targeting only a small subset of cells

Integration

We provide a one stop shop to meet all your CDC development needs

Developability

Our CDCs are IP-free. You have full ownership of the products which can be translated into the clinic.