Cell Membrane-based Surface Engineering Technology

Creative Biolabs is a leading service company with robust and standardized cell surface engineering technologies supporting our customers' specific project requirements.

Cell Membrane-based Surface Engineering Technology

Cell membrane-based therapeutics have been widely investigated in many fields. The simple and powerful methods that engineer the cell membrane to introduce novel functions is highly desirable for cell membrane-based drug delivery. Creative Biolabs is a reliable partner for your cell membrane-based surface engineering development demands by providing high-quality and customized solutions and services. Our specialized scientist team provides novel cell membrane-based surface engineering technologies, including but not limited to cell membrane-based ligand modification technology and cell membrane coating technology. Through these fast, simple, and cost-effective techniques, ligands can be efficiently conjugated without the need for genetic modification of host cells, and the functional cell membrane-coated nanoparticles (CM-NPs) can be rapidly developed for many applications.

• Cell Membrane-based Ligand Modification Technology

Creative Biolabs has years' experience in cell membrane engineering and will offer you the best advice and support based on our cell membrane-based ligand modification technology. We have developed several non-genetic cell membrane modification approaches to functionalize cell membranes, such as physical attachment and chemical modifications. Through these functionalization approaches, the original properties of the natural cell membranes could be maintained while adding desired functions. In this case, cell membrane functionalized with tumor-targeting ligands represents a promising approach that is ultimately applied for the treatment of a wide range of cancers through tumor-targeted drug delivery.

Fig.1 Cell membrane-based ligand modification. (Fang, 2013)

• Cell Membrane Coating Technology

Recently, the direct use of naturally derived biomembrane as a coating material represents an emerging strategy for nanoparticle (NP) functionalization. With our state-of-the-art cell surface engineering platform, Creative Biolabs provides cell membrane coating technology, an approach to the biomimetic replication of cell membrane properties, to effectively support your specific CM-NPs development projects. Many different types of NPs are available based on our cell membrane coating technology, including but not limited to polymers, liposomes, silica, iron oxide NPs, metal materials, new two-dimensional materials, and some drug formulations (e.g., micelles, nanogel, and nanocrystals). This advanced cell membrane coating strategy could be highly utilized for various purposes, including drug delivery, imaging and phototherapy, detoxification, and immunotherapy.

Fig.2 Cell membrane coating. (Rao, 2016)

Creative Biolabs is a leading service provider with many years of experience in cell membrane-based surface engineering. We would be pleased to provide support for any of your questions. What you need to do is feel free to contact us or send us your specific demands. Our professional scientist will reply to you as soon as possible.

References

1. Fang, R.H.; et al. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale. 2013, 5(19), pp.8884-8888.
2. Rao, L.; et al. Synthetic nanoparticles camouflaged with biomimetic erythrocyte membranes for reduced reticuloendothelial system uptake. Nanotechnology. 2016, 27(8), p.085106.