Cancer Cell Membrane-coated Nanoparticle (CC-NP) Engineering Technology

As one of the top CRO companies in the field of cell-surface conjugation discovery for disease treatment, Creative Biolabs has focused on cell-membrane coating technology services for years and has accomplished numerous challenging projects in this field. Currently, we have an entrepreneurial team of highly-skilled and qualified experts in cancer cell membrane-coated nanoparticle (CC-NP) design, evaluation, as well as optimization. The members have originated from a rich academic research background, bringing their experience into translation. We are very proud of providing high-quality, omnidirectional custom CC-NP solutions or products to our valued clients and to remove the difficulties of your projects.

Introduction to Cancer and Cell-derived NPs

In the past few decades, cancer has become a serious threat to human health due to the high fatality rate and lack of targeted drugs in the clinic. Up to now, a variety of conventional methods, including chemotherapy, radiotherapy, and drugs, have been generated for improving patient outcomes. However, many studies have demonstrated that some of these treatments are ineffective and may cause unexpected side effects because they can also kill normal cells and lead to tumor metastasis. As a consequence, many attempts have been made to develop suitable targeted therapies that can improve efficacy and reduce toxicity. Recently, cell-derived NPs has been regarded as a powerful tool for treating various cancers. These NPs can exhibit many of the natural properties of the source cells. Furthermore, various types of NPs have been combined with the cancer cell membrane to trigger enough tumor-specific immune responses in different applications, such as drug delivery, tumor imaging, as well as immune stimulation.

Fig.1 Illustration of the synthesis of membrane-wrapped nanoparticles. (Harris, 2019)

Our CC-NP Technology

Nowadays, CC-NPs plays a significant role in improving the efficacy of cancer drug delivery and increasing the immunogenicity of disease treatment potency. It has become a unique approach to completely deliver surface antigen diversity of the source cells. Moreover, recent studies have indicated that CC-NPs can provide superior tumor targeting capabilities and continuous accumulation in tumors and metastases. Therefore, CC-NPs technology has been considered as an attractive way to the development of targeted cancer therapy. Through our full spectrum of early discovery, nonclinical, and commercialization services, Creative Biolabs is committed to developing the most promising CCNP-technology for cell-surface conjugation.

In our company, the synthesis of CC-NPs consists of several steps: (1) cancer cell membrane extraction, (2) production of the nanoparticulate core, (3) membrane coating material selection, (4) fusion of core NPs and cancer cell membrane. Normally, membrane extraction needs to remove the components from the membrane but ensure the integrity of membrane functional components. Meanwhile, a wide battery of materials, such as gold nanocages, nanocrystal, polymers, minerals, as well as gold-based nanospheres, will be selected for CC-NP core design. Besides, a range of methods, including physical extrusion and microfluidic coating, for fusing membrane vesicles with CC-NP cores, have been generated by our labs to enhance drug delivery, tumor imaging, or more effective immunotherapy.

Fig.2 Characterization of cell-membrane coated nanoparticles. (Zhai, 2017)

Service Highlight

• One-stop solution for cell-surface conjugation
• A large number of nanomaterials for NP cores
• The abundant stock of particle sizes
• Surface chemistry and particle stabilization experience

By continuing to grow in response to the requirements of our clients, Creative Biolabs is dedicated to exploring novel and innovative CC-NP technologies to offer the most comprehensive, integrated portfolio of CC-NP products and solutions. If you are interested in our services, please feel free to contact us for closer communication to learn how we can be involved in your project. Separate services or integrated end-to-end solutions are all welcomed.

References

1. Harris, J. C., et al. Cancer cell membrane-coated nanoparticles for cancer management. Cancers. 2019, 11(12): 1836.
2. Zhai, Y., et al. Preparation and application of cell membrane-camouflaged nanoparticles for cancer therapy. Theranostics. 2017, 7(10): 2575.