Hybrid Cell Membrane-coated Nanoparticles Engineering Technology

Nanotechnology provides a method to fabricate nanoparticles. To improve drug delivery, photodynamic therapy, phototherapy, immunotherapy, and imaging, smart multifunctional nanoparticles are designed. Hybrid cell membrane-camouflaged nanoparticles (HC-NP) mainly encompass the extent-circulating erythrocyte membrane and platelet membrane, as well as cancer cell membrane with homotypic binding. The hybrid cell membrane coating approach can desirably integrate different biological functions into a biomimetic nanoplatform. Creative Biolabs provides a full range of services in cell membrane coating technology to meet the need of our clients.

Introduction of HC-NP Engineering Technology

Cell membrane-camouflaged nanoparticles such as synthetic nanoparticle core coated with a layer of the natural cell membrane inherit unique and inherent features of the original cells and the synthetic nanoparticle. Furthermore, to increase cellular and molecular transmission, prolong circulation time, enable easy penetration of biological barriers, and control the release of the loaded drug, the surface features and physicochemical properties of the nanoparticles can be tailored. Camouflaging synthetic nanoparticles with hybrid cell membrane has been extensively highlighted in recent years. The resultant biomimetic nanoparticles not only reserve the physicochemical properties of the synthetic nanoparticles but also inherit the biological functions of source cells. Because the biological functionality comes from different source cells, the criteria for selecting the cell membranes mainly depend on the unique features of source cells and the requirements of disease therapy.

Fig.1 HC-NP designed for cancer diagnosis and treatment. (Chen, 2020)

Case Study of HC-NP Engineering Technology

• Case 1

An erythrocyte-platelet hybrid membrane-camouflaged nanoparticle was developed with surface membrane protein markers from the two cells. The resulting dual membrane-camouflaged nanoparticles exhibited outstanding long circulation and distribution in mouse models.

• Case 2

A class of personalized biomimetic nanoparticles by wrapping erythrocyte-B16 hybrid cell membrane around CuS nanoparticles was developed to avoid macrophage phagocytosis and enhance homogeneous targeting.

• Case 3

To escape immune capture and prolong their survival in systemic circulation time, a multifunctional biomimetic nanoplatform was prepared in which platelet-cancer stem cell hybrid membrane was coated onto iron oxide magnetic nanoparticles. These nanoparticles exhibited favorable photothermal therapy for antitumor therapy.

HC-NP Engineering Technology Services

With years of experience in cell membrane coating technology, Creative Biolabs is dedicated to offering high-quality HC-NP engineering technology services to modulate their function and interactions. Our strategies used to prepare HC-NP include four main steps: synthesizing nanoparticle cores, isolating and extracting different cell membranes, preparing hybrid cell membrane-derived vesicles, and finally wrapping around the nanoparticle with the hybrid cell membrane-derived vesicles. In addition, multiple types of cell membrane coating technology could be provided at Creative Biolabs. Please contact us for more detailed information to know how we can help.

Reference

1. Chen, H.Y.; et al. Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy. Acta Biomaterialia. 2020, 112.