Platelets Membrane-coated Nanoparticle (PLT-NP) Engineering Technology

As a well-established company in the bio-industry, Creative Biolabs offers a full range of cell membrane-based surface engineering services. Guaranteed to perform within the specified time frame, and the quality of cell membrane conjugation research is always maintained to the end. Our laboratory services have many advanced research tools, such as platelets membrane-coated nanoparticle (PLT-NP) engineering technology, to support customer's needs in the fast-growing cell-surface conjugate discovery projects.

Introduction to Cell Membrane Coating and Nanoparticles

Currently, cell membrane coating technology has been regarded as an effective way to analyze the cell membrane and has been broadly used in many fields, such as nanoscale biomedicine. Meanwhile, pilot studies have demonstrated that nanoparticles (NPs) coated with cell membranes can provide new insights to combine nature cell membrane traits with artificial core material modification technology. Furthermore, numerous data have revealed that NPs play an important role in drug delivery, diagnostic imaging, as well as cell surface conjugation. NPs can prevent carriers inactivation or degradation, improve the efficiency of targeted, regulate drug release process and carry out mass production. As a result, cell membrane-based NPs, including PLT-NP, have been widely generated and have attracted wide attention as powerful targeted drug delivery tools and controllable drug release systems.

Fig.1 Schematic illustration of the targeted delivery of platelet membrane-coated nanoparticles. (He, 2018)

Our PLT-NP Technology

In recent years, platelets, a group of blood cells, have emerged as a key factor in regulating coagulation, immune responses, and hemostasis. Moreover, the use of platelet membrane for NP coating has become a popular method for measuring the interaction between the cell surface and physiological environment.

With the commitment of being your best cell membrane conjugation service provider, Creative Biolabs has established the utmost efficient PLT-NP engineering technology for developing various cell-surface conjugates in disease treatment. For instance, several PLT-NPs have been designed and applied in coating thermal spectrum reagents and antitumor drugs to improve the efficacy of photothermal conversion and reduce the side effects of cancer therapy. In general, platelet membranes will be coated with specific NPs, such as Fe₃O₄, to obtain the ability of long-term targeting, imaging, optical absorption capabilities. Besides, the results have shown that our PLT-NPs can also protect rapidly oxidizing NPs from exposure to oxygen or normal tissues.

Fig.2 In vitro drug release profiles of CS-PLGA, CS-pPLGA, and PLTM-CS-pPLGA NPs. (Wang, 2019)

Why Choose Us?

Nowadays, Creative Biolabs is pleased to share our extensive expertise in the field of PLT-NP technology with our customers. We offer high-quality customized services to develop well-validated and highly published PLT-NP design, evaluation, and optimization assays with your PLT-NPs-of-interest. Up to now, We are building a team of talented and motivated scientists and technicians to pursue our commitment and has successfully provided a series of cell-surface conjugates for accelerating the disease therapy process.

• Well-mature PLT-NPs development system
• Advanced platelet membranes coating platforms
• Cost-effective and efficient service chain
• Timely data feedback to facilitate the process of your project

Creative Biolabs is a leader in the field of PLT-NPs design and PLT-NPs technology discovery for years. With our extensive experience and advanced platform, we can provide a series of cell membrane coating services based on a wide variety of state-of-the-art PLT-NPs technologies. We are proud to partner with our clients on the journey of bringing novel PLT-NPs to different clinical applications. If you are interested in our services, please contact us for more details. Let us know what you need and we will accommodate you. We look forward to working with you in the future.

References

1. He, Y., et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Research. 2018, 11(11): 6086-6101.
2. Wang, H., et al. Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery. Journal of nanobiotechnology. 2019, 17(1): 1-16.